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New York - Robinson Cano homered twice and hit one of three straight long balls off an ineffective Johan Santana to lead the New York Yankees to a 9-1 rout of the Mets on Friday night.
Hiroki Kuroda allowed one hit in seven scoreless innings before leaving with a bruised left foot. Cano ended Santana's bid for a second straight no-hitter with a two-run shot in the second, then connected again in the third to begin a string of three consecutive home runs by the Yankees.
In the first Subway Series matchup of the season, Kuroda (5-6) gave up only a two-out double in the sixth to Omar Quintanilla.
Santana (3-3) was given two extra days of rest after throwing a career-high 134 pitches last Friday against St. Louis in the first no-hitter in Mets history.
But he didn't have it this time, serving up a career-high four homers during New York's fourth loss in five games
Kuroda's first appearance in the crosstown rivalry was cut short when Daniel Murphy scorched a liner off the pitcher's foot, eliciting "oohs" from the crowd of 48,566 - just the second sellout at Yankee Stadium this season. The ball popped up high and was caught by third baseman Alex Rodriguez for the final out of the seventh.
Kuroda limped off the field and down into the Yankee Stadium clubhouse, followed by several teammates and trainers.
Cody Eppley worked the eighth and former Mets reliever Ryota Igarashi gave up an RBI double to Lucas Duda in the ninth in his Yankees debut before finishing the two-hitter.
With Jose Reyes in Miami, Mariano Rivera preparing for knee surgery and Kuroda on the mound, the start of 16th Subway Series had a different look.
The Mets, who slashed $49 million from their payroll last offseason, have a roster full of youngsters participating in their first game between the New York teams.