Boston - One ball fell between two outfielders. Another took a bad hop off the Green Monster standings. One batter reached safely on a dropped third strike and another when the pitcher was slow to cover first.

By the time it was over, the Boston Red Sox had scored five runs in the fourth inning, taking advantage of Tampa Bay's bad luck and bad defense to overcome an early deficit and beat the Rays 12-2 on Friday in Game 1 of the AL division series.

"You play 162 games, a lot of innings, a lot of pitches, a lot of runs. One thing you can guarantee in the playoffs is you're going to see something you haven't seen all year," said Jonny Gomes, who doubled to tie the game and then scored from second on an infield single to give Boston the lead for good. "And we saw that right away."

Needing a 163rd game to earn a wild-card berth, the Rays won three win-or-go-home games in three different cities to reach this series. Now they need a victory in Game 2 today to tie the best-of-five series before it shifts to St. Petersburg, Fla., for Games 3 and 4.

"We've been playing very well. We've not been making any mistakes. We made a bunch tonight," Tampa Bay manager Joe Maddon said. "But I've also learned one other thing regarding baseball: 24 hours can make a huge difference. That's just one game, baby. That's just one. We'll be back tomorrow, I promise you. We'll be ready to play. We will not be affected mentally by tonight's game."

Jon Lester allowed three hits in 7 2-3 innings for the AL East champions, giving up solo homers to Sean Rodriguez and Ben Zobrist to spot the Rays a 2-0 lead through the top of the fourth. Tampa Bay starter Matt Moore had still not given up a hit.

But Dustin Pedroia led off the bottom half with a single up the middle, and then David Ortiz hit a high fly ball that center fielder Desmond Jennings and right fielder Wil Myers converged on. The Rays rookie raised his right hand to call off Jennings but let it fall behind him and bounce off the warning track and into the bullpen for a double.

"I was under the ball and I saw Des out of the corner of my eye and backed off," Myers said. "I messed it up, and it won't happen again. ... That play kind of gave them a spark, and a good team takes advantage of it."

With a derisive cheer of "Myers" echoing through the ballpark, Mike Napoli popped up to second base for the first out before Gomes hit a fly ball that scraped the left-field wall on the way down. Pedroia held to tag up, then scored easily with Ortiz coming in just a few steps behind him to make it 2-2.

Jarrod Saltalamacchia struck out before Stephen Drew hit a slow hopper to first that James Loney fielded and flicked to Moore. But the pitcher's foot came down a split second after Drew's; with Moore facing the wrong way, Gomes never slowed down as he rounded third and scored without a throw.

Will Middlebrooks followed with a line drive to left that took a bad hop off the Monster where the AL East standings are posted, and it got past Rodriguez on the rebound. That allowed Drew to score and make it 4-2, while Middlebrooks went into second with a double.

Jacoby Ellsbury reached on a passed ball on strike three - which would have been the third out of the inning - and Middlebrooks moved to third, where he scored on Shane Victorino's single to make it 5-2.

None of the misplays was scored an error.

"That Myers play obviously gave us some momentum," Victorino said. "All those kind of things and it became a snowball effect. Plays like that happen. You've got to thrive and you've got to get as many runs as you can when a mistake like that is made."

The Red Sox added three more runs to chase Moore in the fifth inning, when they sent nine batters to the plate - the first time in franchise history they have batted around in consecutive innings in a postseason game. In all, Moore was charged with eight runs - seven earned - on eight hits, two walks a hit batter and a wild pitch, striking out four in 4 1-3 innings.

Lester struck out the first four batters he faced, but gave up homers over the Monster to Rodriguez in the second and Zobrist in the fourth. In all, he allowed three hits and three walks while striking out seven before leaving with two on and two out in the eighth.

Junichi Tazawa got Myers on a line drive to right to end the eighth, and extra starter Ryan Dempster got the last three outs. Victorino had three hits and Saltalamacchia had three RBIs for the Red Sox, who tied for the best record in baseball this season a year after finishing last.

Every Boston starter got a hit and scored a run, the first time a team had done that in the postseason since Lou Gehrig, Joe DiMaggio and the Yankees in the 1936 World Series.

"No longer it's the best team, it's the hottest team," Gomes said. "And we obviously know Tampa is coming in hot, coming in on a roll. So it took a couple of innings to break the ice, but once Petey got that hit up the middle, I think that took a lot of questions out."