American League

Blue Jays 12, Rays 7

Jose Bautista and rookies Devon Travis and Dalton Pompey homered to back Mark Buehrle, Kevin Pillar made a leaping catch at the left-field wall to deny a home run and Toronto beat Tampa Bay on Wednesday to stop the Rays' four-game winning streak.

Bautista hit a two-run homer in the first off Erasmo Ramirez (0-2), sparking the Blue Jays to what would be an 9-0 lead after four innings. Donaldson hit a two-run single in a three-run second after narrowly missing a grand slam down the left-field line.

Pillar and Travis added RBI singles in the third, and Justin Smoak singled in two runs in the fourth — his first RBIs for the Blue Jays.

Donaldson had three hits and three RBIs before a crowd of 15,086, the Blue Jays' smallest at the Rogers Centre since 14,086 against Cleveland last May 14, according to STATS.

Angels 10, Rangers 2

Mike Trout had three hits, scored twice and drove in a run to back another win in Texas for Hector Santiago as Los Angeles beat the Rangers.

Santiago (1-1) allowed one run and four hits over seven innings, improving to 4-0 with a 2.15 ERA in five career starts at Texas.

Los Angeles scored six runs in the second off Anthony Ranaudo (0-1), who made his Texas debut while starting in place of injured Derek Holland.

Indians 4, White Sox 2

Trevor Bauer (2-0) won consecutive starts for the first time in his three-plus seasons in the major leagues, helping Cleveland stop a four-game losing streak,

Making his 36th big league start, Bauer (2-0) gave up two runs, four hits and four walks in six innings with eight strikeouts. Cody Allen struck out Jose Abreu with two on and two outs in the ninth for his second save.

John Danks (0-2) gave up four runs — three earned — and six hits in 4 2-3 innings.

Twins 3, Royals 1

Kansas City became the last team in the majors to lose this season, as Kyle Gibson pitched into the seventh inning and Oswaldo Arcia hit a two-run homer for Minnesota.

The Royals (7-1) were chasing the 2003 team’s 9-0 start as the best in franchise history, but Gibson (1-1) used 12 groundball outs and three strikeouts to keep the highest-scoring team in the majors quiet for a night.

The Twins (2-6) went 1-8 to begin the 1994 season, the only other time in the club’s 55-year history they started with seven losses in their first eight games. Glen Perkins pitched a perfect ninth for his first save.

Edinson Volquez (1-1) struck out seven in 7 2-3 innings, with five hits and one walk allowed. He loaded the bases with no outs in the first, but he escaped with only Brian Dozier’s sacrifice fly as the damage.

Astros 6, Athletics 1

Collin McHugh struck out 11, and Jed Lowrie hit one of three homers for Houston in a win over Oakland.

Luis Valbuena and Evan Gattis also homered for the Astros, who matched their season high in scoring.

Houston’s bats are finally starting to show signs of life after being held to two runs or less in six of their first eight games.

The A’s have been outscored 32-14 in their five losses, compared to a 42-1 margin in their five wins.

McHugh (2-0) allowed six hits and one run in 5 2-3 innings. McHugh is the only Astros starter to earn a win since Dallas Keuchel’s opening-day victory.

McHugh was relieved by Tony Sipp with two outs in the sixth after Ike Davis doubled.

Oakland starter Drew Pomeranz (1-1) followed his masterful two-hit, seven-inning performance against Seattle by allowing four runs and six hits in five innings.

National League

Marlins 6, Braves 2

Dan Haren (1-0) gave up three hits in seven innings and Adeiny Hechavarria went 3 for 3 with a homer and three RBIs as Miami won consecutive games for the first time this season.

Atlanta’s Eric Stults (0-1) gave up four runs and five hits in five innings.

Marlins slugger Giancarlo Stanton batted without a protective mask on the left side of his batting helmet when facing left-handers. Stanton, who went 0 for 4, is still wearing the mask against right-handers.

Rockies 4, Giants 2

The catch of his career one night, a three-run homer the next for Nolan Arenado, who put Colorado on the board in the first inning and saw it hold up as the first-place Rockies completed a sweep of San Francisco.

Tyler Matzek (1-0) outpitched two-time NL Cy Young Award winner Tim Lincecum, retiring 12 of 13 batters during one stretch. The NL West-leading Rockies extended the best road start in franchise history to 6-0 while sending the reigning World Series champions to a sixth straight defeat.

Charlie Blackmon added a sacrifice fly for the Rockies, who at 7-2 have matched the best nine-game start in franchise history by joining the 1995, '97 and 2011 clubs.

Matt Duffy hit his first career home run with a solo drive in the eighth off Boone Logan for the Giants. Angel Pagan added an RBI single in the first.

Cubs 5, Reds 0

Travis Wood pitched three-hit ball into the eighth inning and Anthony Rizzo hit his first home run of the season, leading Chicago to a victory over Cincinnati.

The Cubs (5-3) won two of three games in the series and moved back into first place in the National League Central.

Wood (1-1) walked two and struck out seven. It was a nice bounce-back from his first start of the season in Colorado where he yielded three runs on seven hits in 4 innings.

Cincinnati starter Jason Marquis (0-1) was in trouble from the outset, allowing five runs — four earned — on seven hits in four innings.

Cardinals 4, Brewers 2

Lance Lynn extended his April success with five solid innings and Matt Holliday had a two-run single in the first inning, lifting St. Louis to a win over Milwaukee.

Lynn (1-1) allowed one run and six hits. He pushed his April record to 13-2 since 2012, the best record in the majors over that period.

Wily Peralta (0-1) gave up four runs on 10 hits over five innings for Milwaukee.

Yadier Molina had three hits for St. Louis, which won 12 of 19 against Brewers last season.

Kevin Siegrist, Seth Maness, Matt Belisle, Randy Choate, Jordan Walden and Trevor Rosenthal followed Lynn. Rosenthal picked up his third save despite giving up a two-out run-scoring hit to Ryan Braun in the ninth.

Padres 3, Diamondbacks 2

Justin Upton homered with two outs in the eighth inning to give San Diego a victory over Arizona.

Upton, one of several star players obtained in an offseason roster revamp, hit the first pitch he saw from Randall Delgado (0-1) into the seats in left. It was his third. Upton also homered in a 5-1 win Tuesday night.

Craig Kimbrel pitched the ninth for his third save in as many chances since joining the Padres the day before the season opener.

Joaquin Benoit (3-0) pitched the eighth for the win.

Yasmany Tomas, Arizona’s heralded 24-year-old prospect, made his big league debut as a pinch-hitter in the seventh and grounded out to second to end the inning.

Paul Goldschmidt gave the Diamondbacks a 2-0 lead with his opposite-field home run to right off Brandon Morrow with one out in the first off second. It was third homer of the season and his 500th career hit. Ender Inciarte was aboard on a leadoff single.

Interleague

Tigers 1, Pirates 0

Alfredo Simon gave up two hits over eight dominant innings, and Detroit beat Pittsburgh.

New London's Rajai Davis hit a leadoff homer in the sixth against Francisco Liriano (0-1) as Detroit shut out Pittsburgh for the second straight day. Joakim Soria worked a perfect ninth for his fourth save while filling in for injured Joe Nathan.

Detroit won two of three in the interleague series despite scoring just seven runs. Simon (2-0) struck out only two but took advantage of solid defense behind him as the Tigers handed Pittsburgh consecutive home losses for the first time since last August.

Detroit had just five hits off four Pittsburgh pitchers but received all the offense it would need when Davis hit his first home run of the season.

Dodgers 5, Mariners 2

Brett Anderson posted his first victory with Los Angeles, Scott Van Slyke hit a two-run double, and the two-time defending NL West champions completed a three-game sweep of Seattle.

Anderson (1-0) allowed two runs — one earned — and six hits over five innings and struck out three in the annual Civil Rights Game, which included a pregame ceremony celebrating the 68th anniversary of Jackie Robinson's major league debut.

Pedro Baez, one of several relievers manager Don Mattingly is leaning on in the absence of injured closer Kenley Jansen, pitched 1 1-3 scoreless innings and J.P. Howell got two outs for his first save since June 12, 2011, with Tampa Bay.

Taijuan Walker (0-1) gave up five runs, six hits and four walks in four innings.