Bills 21, Packers 13

Veteran Mario Williams and third-string newcomer Bacarri Rambo made for an unlikely Buffalo Bills defensive duo.

They played havoc with Aaron Rodgers and the Green Bay Packers in a victory on Sunday.

Rambo, filling in after backup safety Duke Williams was hurt early in the third quarter, intercepted Rodgers on consecutive drives in the second half. Williams helped seal the victory when he forced Rodgers to fumble into the end zone, which led to a safety when running back Eddie Lacy picked up the ball with 1:51 left.

The play was whistled dead at that point, because only Rodgers was allowed to advance the ball with under 2 minutes remaining.

Marcus Thigpen scored on a 75-yard punt return, and Dan Carpenter hit all three field goal attempts, including a 51-yarder in the second half to help keep Buffalo (8-6) in the AFC playoff picture. The Bills are assured their first eight-win season since going 9-7 in 2004.

The Packers (10-4) had a five-game win streak snapped, and squandered an opportunity to get closer to their sixth consecutive playoff berth.

Rodgers finished 17 of 42 for 185 yards and two interceptions. It was an unlikely meltdown for Rodgers and the offense that entered the game on a tremendous roll.

Rodgers had been picked off just three times this season, and none since throwing two in Green Bay's last loss, 44-23 at New Orleans on Oct. 26. The Packers were limited to Lacy's 1-yard touchdown run and two field goals by Mason Crosby.

This from a team coming off a 43-37 win over Atlanta and that had outscored its past five opponents by 210-113. Rodgers combined for 1,580 yards passing with 16 touchdowns and no turnovers in his previous five games.

All that came to a halt against a dominating Bills defense that last week contained Peyton Manning. Despite a 24-17 loss at Denver, the Bills ended Manning's 51-game streak with a touchdown pass.

The Bills acquired Rambo last month after cornerback Leodis McKelvin sustained a season-ending ankle injury. Rambo had played 13 games with Washington before being cut after Week 2 this season.

Bengals 30, Browns 0

Johnny Manziel spent his first NFL start being chased and taunted by Cincinnati defenders as the Bengals rudely welcomed the hyped rookie quarterback to the league with a 3 demolition of Cleveland.

Manziel failed to live up to the overwhelming buildup surrounding his debut as the AFC North-leading Bengals (9-4-1) built a 20-point halftime lead and rolled to their fourth straight road win.

Bengals rookie Jeremy Hill rushed for 148 yards and two touchdowns, backing up his postgame trash talk of the Browns following a loss to them last month.

Manziel, promoted over the slumping Brian Hoyer to spark the Browns (7-7), finished 10 of 18 for 80 yards and two interceptions. He was sacked three times, under pressure all afternoon and had Bengals players imitating his signature "money-rubbing" gesture more than once.

Broncos 22, Chargers 10

Peyton Manning played through a thigh injury and flu-like symptoms and Connor Barth kicked five field goals to lead Denver to a fourth straight AFC West title.

Manning came out of the game late in the second quarter. He apparently hurt his thigh while blocking linebacker Donald Butler on a run by C.J. Anderson.

He returned for the start of the third quarter and on Denver's second possession threw a 28-yard touchdown pass to Demaryius Thomas to give the Broncos a 16-3 lead.

The Broncos (11-3) won their fourth straight game. Denver's 12th straight division road win tied San Francisco's NFL record set from 1987-90.

Colts 17, Texans 10

Andrew Luck threw two touchdown passes and the Colts won their second straight AFC South title.

Indianapolis (10-4) has won four straight.

It sure wasn't easy. Luck was 18 of 34 with 187 yards and one interception on the same day Reggie Wayne passed Peyton Manning for the most games and wins in franchise history. Wayne has played in 209 games, winning 142.

Houston (7-7) lost starting quarterback Ryan Fitzpatrick with a left leg injury in the second quarter. Rookie Tom Savage replaced Fitzpatrick and was ineffective, going 10 of 19 for 127 yards.

The Texans took a 7-0 lead on Kendrick Lewis' 27-yard interception return. Luck tied it with a 26-yard pass to Hakeem Nicks. Luck hooked up with Dwayne Allen on a 3-yard pass to make it 14-7 before halftime. Indy sealed it with a late field goal.

Seahawks 17, 49ers 7

Marshawn Lynch rushed for 91 yards and a touchdown, Russell Wilson threw a touchdown pass to rookie Paul Richardson, and the Seahawks knocked archrival San Francisco from playoff contention.

The defending Super Bowl champions remained in contention for a division title and No. 1 seed in the NFC.

After a sluggish, sloppy first half, Seattle (10-4) awoke in the final 30 minutes behind the running of Lynch and a defense that shut out the 49ers, holding them to 67 yards. Colin Kaepernick was sacked six times and the 49ers didn't run a play past the Seattle 38 in the second half.

Lynch scored on a 4-yard run late in the third quarter and the Seahawks took advantage of a short field on their next drive, capped by Wilson's strike to Richardson.

The loss and Detroit's win eliminated San Francisco (7-7) from contention.

Lions 16, Vikings 14

Matt Prater's 33-yard field goal with 3:38 remaining lifted Detroit into a tie for first place in the NFC North.

The Lions (10-4) are now even atop the division with Green Bay, which lost to Buffalo earlier in the day, but Detroit didn't have an easy time, spotting the Vikings (6-8) a 14-0 lead before a pair of second-quarter interceptions helped the Lions start their rally.

Even at the end, Detroit had to sweat out a 68-yard field goal attempt by Minnesota's Blair Walsh on the game's final play. The kick was short.

Steelers 27, Falcons 20

Ben Roethlisberger threw for 360 yards and William Gay returned an interception for a touchdown as the Steelers (9-5) remained a half-game behind Cincinnati in the AFC North with their second straight win.

The Falcons (5-9) ensured themselves of a losing season and slipped out of first place in the NFC South.

Pittsburgh led 13-0 after Gay picked off Matt Ryan's pass over the middle on the first play of the second quarter, returning it 52 yards. The Steelers extended the lead to 27-13 with Le'Veon Bell's 1-yard run in the opening minute of the fourth period.

The Falcons made a game of it, pulling within a touchdown on Ryan's 4-yard pass to Roddy White. But the Steelers clinched the victory with their final possession, converting twice on third down to run out the clock.

Ravens 20, Jaguars 12

The Ravens sacked rookie Blake Bortles eight times and returned a blocked punt for a touchdown.

Baltimore (9-5) gained only 31 yards rushing through three quarters and scored just once with its offense on the field. But the defense was solid, and special teams helped the Ravens stay in the thick of the AFC playoff chase.

Terrell Suggs was credited with 2 1-2 sacks and rookie Timmy Jernigan, starting for the suspended Haloti Ngata, had two.

Jacksonville (2-12) tried just about everything in its bid to pull off an upset, including an onside kick and a fake punt. Both worked, but it wasn't enough to earn the Jaguars their first win on the road.

Panthers 19, Buccaneers 17

Derek Anderson threw for 277 yards and a touchdown, Graham Gano kicked four field goals and the Panthers improved their chances in the NFC South playoff race.

The win, coupled with Atlanta's loss to Pittsburgh, left the Panthers a half-game behind New Orleans in the division. Carolina (5-8-1) can move into first place if the Saints lose to Chicago on Monday night.

Anderson was 25 of 40 and improved to 2-0 as a starter in place of Cam Newton, sidelined while recovering from a car accident Tuesday that left him with two fractures in his lower back.

Chiefs 31, Raiders 13

Alex Smith threw for 297 yards and two scores, while Kansas City shut down Derek Carr and the Oakland offense.

Knile Davis had touchdowns running and receiving, and De'Anthony Thomas returned a punt 81 yards for another score as the Chiefs (8-6) got even for a 24-20 loss to Oakland (2-12) last month.

The Chiefs led 10-6 early in the third quarter before scoring three touchdowns in 4 minutes, 42 seconds. The last was a 70-yard throw from Smith to Davis, who had taken over the majority of running back duties after Jamaal Charles took a shot to the head.

Charles passed concussion testing and returned briefly to the game.

Carr finished 27 of 56 for 222 yards, throwing a TD pass in the final minute.

 Cowboys 38, Eagles 27 

Dez Bryant caught a career-best three touchdown catches from Tony Romo and Dallas rallied to beat Philadelphia after wasting a 21-0 lead. 

DeMarco Murray had a pair of TD runs to help the Cowboys (10-4) move ahead of the Eagles (9-5) into first place in the NFC East. The Eagles dominated the Cowboys in a 33-10 road win on Thanksgiving, but Dallas takes control of the division with two weeks left. 

The Cowboys jumped to a 21-0 lead early in the second quarter before Philadelphia rallied behind Mark Sanchez. 

Chris Polk had TD runs of 1 and 5 yards and Darren Sproles ran in from the 1 to give the Eagles a 24-21 lead late in third quarter. But Romo and the Cowboys answered quickly with two touchdowns in a span of 2:51. 

Murray scored on a 2-yard run to cap a 78-yard drive. J.J. Wilcox then intercepted Sanchez's pass and the Cowboys started the fourth quarter at the Eagles 42. Romo then hit Bryant in stride for a 25-yard scoring pass.