New York - Coco Crisp homered twice and drove in five runs, going 4 for 4 with a three-run shot in the 10th inning that sent the Oakland Athletics to a 6-4 win over the New York Yankees on Wednesday night.

The loss knocked the Yankees out of first place in the AL East, dropping them behind Boston when the Red Sox finished a 13-2 rout of Texas.

No. 9 batter Scott Sizemore was 4 for 4 with a tying double off CC Sabathia in the eighth and Oakland won at Yankee Stadium for the second consecutive night to clinch a series victory. The A's had lost 10 straight series against New York, an Oakland record for futility against any team.

Nick Swisher homered twice and Mark Teixeira also connected for the Yankees, who played without Alex Rodriguez (sprained left thumb) for the second straight night. New York had dropped only two of its previous 20 series since June 10.

Oakland goes for a three-game sweep Thursday afternoon with Rich Harden on the mound.

Trevor Cahill finally held New York in check and the A's improved to 7-26 against the Yankees since 2008. The last time Oakland won a series against New York was the summer of 2007, when they took two of three at old Yankee Stadium.

Crisp also walked during a perfect night at the plate and matched his career highs for hits and RBIs. The A's have won six of eight following a four-game skid.

Fautino De Los Santos (2-0) struck out two in a perfect ninth for the win. Andrew Bailey earned his 18th save in 20 chances, closing out the Yankees for the second straight night.

He gave up a solo shot with two outs to Swisher, who barely missed a game-winning grand slam against the right-hander Tuesday when the ball was caught at the fence for the final out.

Cliff Pennington and Sizemore singled with one out in the 10th against Rafael Soriano (2-2), who had been very effective since returning July 29 from a long stint on the disabled list. Jemile Weeks struck out but Crisp hit the next pitch into the second deck in right for his seventh homer.

It was the second career multihomer game for Crisp, who went deep from both sides of the plate. The other one came on June 18, 2007, with Boston at Atlanta.

Teixeira tied it in the eighth with a long leadoff homer on a 3-1 pitch from Grant Balfour.

Looking for his 18th win, Sabathia squandered a one-run lead in the eighth. Sizemore tied it with an RBI double and Crisp gave Oakland a 3-2 lead with an RBI single off David Robertson.

Derek Jeter kept it close by stretching out for Hideki Matsui's low liner to shortstop, starting an unassisted double play that ended the inning.

Sabathia gave up a home run to his second batter, Crisp, but little else until the eighth inning. The big lefty also benefited from some sharp defense.

New York opened the sixth with a pinpoint relay when Weeks tried to stretch a long double. Center fielder Curtis Granderson hustled to the ball at the base of the wall and threw to second baseman Robinson Cano, who skillfully snapped off a quick dart to third that barely cut down the speedy Weeks.

With the score tied and nobody out, Weeks probably would have been wise to hold at second. Back in the dugout, interim manager Bob Melvin came over for a quick chat with the rookie.

Swisher put the Yankees ahead 2-1 in the bottom half with an opposite-field homer to left-center off Cahill, who allowed two runs in six-plus innings. The 23-year-old right-hander, an All-Star in 2010, entered 0-4 with a 13.50 ERA in four career starts against New York.

Swisher also had a three-run shot Tuesday night.

Brett Gardner, celebrating his 28th birthday, reached on an infield single in the third. Weeks backhanded the grounder and, with his momentum carrying him away from first base, flipped to shortstop Cliff Pennington, who made a strong throw to first that was just a hair late.

Gardner stole second on a pitchout and scored on a single by Jeter, his fifth hit in five at-bats. That gave the captain 3,055 career hits, tying ex-Yankee Rickey Henderson for 21st place.

NOTES: Harden matched a career high with 11 strikeouts in his most recent outing, a 2-0 victory Friday over Toronto, and is 3-0 with a 1.78 ERA in four starts against AL East clubs. ... RHP Phil Hughes pitches for the Yankees on Thursday and he is also coming off a strong outing. He allowed two hits in 7 2-3 innings Friday at Minnesota. ... Yankees GM Brian Cashman wouldn't comment on reports that the team claimed Chicago Cubs 1B Carlos Pena off trade waivers. ... After the series finale Thursday, New York plays 17 of its next 23 games on the road. ... Cano extended his hitting streak to a season-high 15 games.