Interleague

White Sox 3, Cubs 1

Eloy Jiménez came up in a big spot and delivered. It was exactly how he pictured the moment when he became a professional ballplayer.

With one major twist.

Jiménez hit a tiebreaking two-run homer in the ninth inning in his first game against his first major league organization, helping the White Sox beat the Cubs on Tuesday night.

The 22-year-old Jiménez was a top prospect for the Cubs before he headlined a rare trade with the White Sox for veteran left-hander José Quintana in July 2017. The Jiménez deal will live on in sports bars all over Chicago for many years to come, and the rookie added another wrinkle with one big swing in his first game at Wrigley Field.

"It was a dream come true," he said. "I wanted to hit one at Wrigley, but now with the White Sox it feels really good."

James McCann hit a leadoff single before Jiménez drove a 1-0 pitch from Pedro Strop (1-3) over the wall in left for his 12th homer. Considered one of baseball's top young sluggers, Jiménez has gone deep six times in his last nine games.

"We were hoping he could get a pitch he could handle and obviously he did," White Sox manager Rick Renteria said. "It was a big blow."

Adding another layer to the accomplishment, Jiménez cracked his bat on the swing. He smiled as he proudly displayed the broken lumber after the victory.

"It was an amazing moment," he said.

Evan Marshall (3-0) got two outs for the win and Alex Colomé worked the ninth for his 15th save. Four White Sox relievers combined for four scoreless innings after Iván Nova turned in one of his best starts of the season.

The slumping Cubs kicked off a 10-game homestand with their fourth loss in five games. Kyle Schwarber connected for his 16th homer and Cole Hamels pitched seven effective innings, but that was it for the North Siders.

"We just have to do a better job offensively," manager Joe Maddon said.

Hamels became the 10th left-hander with 2,500 career strikeouts when he threw a called third strike past Nova for the first out of the third. The crowd of 41,192 responded with a big cheer when his accomplishment was displayed on the videoboard, and Hamels tipped his cap in appreciation.

"To do it in front of fans that really understand and get it, that's a very special moment," Hamels said.

Jiménez had a chance to get the White Sox off to a fast start when he batted with the bases loaded in the first. But Hamels got him to bounce into an inning-ending double play.

Schwarber then lined Nova's first pitch of the game into the bleachers in left for his fourth career leadoff homer. He also started Thursday's 7-3 loss to the Dodgers with a home run on Clayton Kershaw's first pitch.

The White Sox tied it in the sixth. Leury García led off with a double and Tim Anderson followed with a hard grounder into the hole at shortstop. Javier Báez made a sliding stop, but he threw wild to first and García hustled home on the error.

Craig Kimbrel took another step toward joining the Cubs when he worked a perfect inning in his first appearance with Triple-A Iowa. The 31-year-old Kimbrel is ramping up after finalizing a three-year contract with Chicago on June 7. The closer could pitch in another minor league game Thursday or Friday.

Cubs general manager Jed Hoyer said the team will use a patient approach with Kyle Hendricks after tests confirmed the right-hander is dealing with a shoulder impingement. Hendricks was placed on the 10-day injured list Saturday, one day after he permitted five runs in 4 1/3 innings in a 5-3 loss to NL West-leading Los Angeles. Tyler Chatwood will take Hendricks' turn in the rotation Thursday against the Mets.

Reds 4, Astros 3

Jesse Winker and Derek Dietrich homered off Justin Verlander in the first inning and Cincinnati beat Houston to clinch its first series win in nearly a month.

The Reds won a series for the first time since May 24-26, when they took two of three from the Cubs. The Astros hadn't dropped a series since April 29-May 2.

Winker connected on the fourth pitch from Verlander (9-3). Joey Votto doubled and Dietrich's first homer since May 28 made it 3-0. Kyle Farmer added a homer in the seventh off.

Verlander went seven innings and struck out eight.

Anthony DeSclafani (4-3) pitched into the sixth inning and gave up six hits. Michael Lorenzen retired the side in order in the ninth for his second straight save and fourth overall.

Tigers 5, Pirates 4

Nicholas Castellanos trotted home when a potential double play in the eighth turned into an RBI fielder's choice due to some indecisiveness by Pittsburgh second baseman Adam Frazier.

The Tigers loaded the bases off Kyle Crick (2-3) with one out when Brandon Dixon hit a grounder that rolled under Crick's glove right to Frazier. Instead of flipping to shortstop Kevin Newman in hopes of turning an inning-ending double play, Frazier tried to tag Detroit's Christin Stewart between first and second. Stewart backed off to avoid the tag, breaking up the play and forcing for Frazier to settle for one out instead of two.

Buck Farmer (4-4) earned the win. Shane Greene earned his American League-leading 21st save. Miguel Cabrera had two hits as Detroit beat the Pirates for just the second time in their last 10 meetings.

Bell hit his 20th home run for Pittsburgh. Jung Ho Kang hit an RBI triple — his first three-base hit since 2015 — and Colin Moran added to Pittsburgh's major-league leading pinch-hit total on an RBI single in the seventh.

American League

Indians 10, Rangers 3

Rookie Zach Plesac allowed only two hits pitching into the eighth inning and Cleveland had four home runs, including three in a row for the first time in nearly 15 years, to overwhelm Texas.

After Jake Bauers led off the Indians' seventh with a 389-foot shot to right-center, Roberto Perez and Tyler Naquin followed with homers that measured more than 400 feet. Those long balls came in a span of five pitches off reliever Drew Smyly. The last time Cleveland had hit back-to-back-to-back homers was at Seattle on July 16, 2004.

Plesac (2-2) struck out six and walked five.

Texas got two of its five overall hits in the ninth, including Willie Calhoun's two-run homer. Rangers starter Adrian Sampson (5-4) allowed five runs (three earned) in three innings.

Jose Ramirez hit a three-run homer for Cleveland.

Angels 3, Blue Jays 1

Tyler Skaggs pitched into the eighth inning, Kole Calhoun and Brian Goodwin hit solo homers and Los Angeles remained unbeaten in five games against Toronto this season.

Skaggs (6-6) went a season-best 7 1/3 innings. He allowed a run and three hits, walked none and struck out six. Ty Buttrey got two outs in the eighth, and Hansel Robles finished for his 11th save in 13 opportunities.

Luis Rengifo had two hits for the Angels, who have won 17 of 23 games in Toronto.

Lourdes Gurriel Jr. homered for the Blue Jays, who have lost a season-worst six straight at home.

Both homers came off right-hander Marcus Stroman (4-9), who allowed two runs and four hits in seven innings. Stroman has lost three of his past four decisions.

National League

Dodgers 9, Giants 0

Clayton Kershaw combined with two relievers on a four-hit shutout, Enriquè Hernàndez had a pinch-hit grand slam to highlight a six-run seventh, and Los Angeles routed San Francisco.

Kershaw (7-1) allowed three hits, struck out six and walked two. The left-handed ace improved to 23-11 in his career against the Giants, who suffered their largest loss of the season.

Dylan Floro struck out three in the eighth. Joe Kelly finished it off in the ninth, giving up a hit and a walk to go with one strikeout.

Rookie Shaun Anderson (2-2) gave up three runs and seven hits in 5 2/3 innings. The right-hander struck out two and walked three.

Joc Pederson hit his 19th homer leading off the game.

Padres 4, Brewers 1

Left-hander Logan Allen threw seven scoreless innings in his major league debut, Francisco Mejia hit a two-run home run and Manny Machado added an RBI double for San Diego over Milwaukee.

The 22-year-old Allen (1-0) was backed by three double plays as well as another dazzling play by rookie shortstop Fernando Tatis Jr. Allen held Milwaukee to three hits while striking out five and walking two.

Brandon Woodruff (8-2) allowed four runs and seven hits in six innings, struck out six and walked one.

Marlins 6, Cardinals 0

Rookie Jordan Yamamoto matched his first career start by pitching seven scoreless innings against St. Louis, and Miami earned the shutout.

Yamamoto (2-0) allowed two hits, struck out seven and walked two. He became the first pitcher since Pittsburgh's Nick Maddox in 1907 to beat the Cardinals twice in a seven-day span when the first game was his debut. Relievers Tayron Guerrero and Sergio Romo completed the two-hitter.

Brian Anderson and Starlin Castro homered for the Marlins.

Jack Flaherty (4-4) pitched seven innings, allowing three runs on four hits while striking out eight, and had St. Louis' first hit off Yamamoto.

Rockies 8, Diamondbacks 1

Nolan Arenado homered and drove in three, Antonio Senzatela pitched one-run ball into the seventh inning and Colorado beat Arizona.

Charlie Blackmon had three hits, and the Rockies (39-35) took over second place in the NL West, a game up on the Diamondbacks, with their sixth straight win against Arizona.

Senzatela (6-5) equaled his longest outing of the season with 6 2/3 innings, allowing seven hits with five strikeouts and four walks.

The Rockies took a 2-0 lead on Arenado's high drive into the left field seats off Arizona's Merrill Kelly (7-7) with two out in the first. It scored Blackmon, who led off the game with a double down the right field line.

Blackmon has reached base in 28 consecutive games, the longest active streak in the National League. He was named NL Player of the Week on Monday after getting 21 hits last week.