East Rutherford, N.J. — Aaron Rodgers was knocked out of the game with an Achilles tendon injury just four plays into his debut for the New York Jets, who rallied behind their defense and stunned the Buffalo Bills 22-16 in overtime on Monday night when rookie Xavier Gipson returned a punt 65 yards for the winning score.

New York's aggressive defense forced four turnovers by Buffalo's Josh Allen, including three interceptions by Jordan Whitehead, in a wild and often ugly season opener. While the Jets concluded their night with coach Robert Saleh joining a celebratory mob in the end zone, the injury to Rodgers cast a pall over their season.

Saleh said after the game that the injury was to Rodgers' Achilles tendon and that the 39-year-old quarterback would have an MRI on Tuesday.

Micheal Clemons forced a fumble by Allen that was recovered by Quinnen Williams, setting up Greg Zuerlein's third field goal — a 30-yarder — with 1:48 remaining to put the Jets ahead for the first time.

But Allen and the Bills had just enough time to get in scoring position again, and Tyler Bass' 50-yard kick hit the left upright before going over the crossbar to tie it at 16-all with 2 seconds left in regulation.

After Buffalo went three-and-out to start overtime, Sam Martin punted 42 yards and Gipson fielded it, made a few moves early and then scampered down the left sideline, made a couple more cuts and zipped into the end zone to set off a huge celebration by his teammates.

Saleh was there to swarm Gipson, an undrafted rookie who made the team out of training camp.

The Jets had tied it at 13 with 4:55 left on an acrobatic catch by Garrett Wilson, who tipped Zach Wilson's pass to himself with his right hand — and Tre'Davious White draped all over him — and corralled the ball as he fell on his back in the end zone.

A night that began with optimism for the Jets turned disappointing before the game was even four minutes old.

Rodgers injured his left ankle when he was sacked by Buffalo's Leonard Floyd and fell awkwardly on the leg. The Jets said X-rays were negative while ruling him out for the rest of the game.

NFL Network reported Rodgers' left foot was in a black walking boot as he was carted to the X-ray room.

After a 26-yard run by Breece Hall on the Jets' opening play, Rodgers threw his first pass away after getting heavy pressure from Gregg Rousseau. Rodgers threw incomplete on the next play, but Terrel Bernard was called for defensive holding.

Then, Rodgers tried to avoid a rushing Floyd, who wrapped up the quarterback and took him down to the MetLife Stadium turf. Rodgers appeared to reach down at his leg before trainers attended to him. He stood up after a few moments, but needed help getting to New York's sideline.

The 39-year-old Rodgers was taken to the blue medical tent to be examined — and then sat on a cart. Halfway to the locker room, he hopped off the cart and limped inside.

Zach Wilson replaced him just 3:45 into the game.