Inter Milan 1, Atlético Madrid 0

Marko Arnautović came off the bench to help Inter Milan to a win over Atlético Madrid in the first leg of the Champions League round of 16 on Tuesday.

Arnautović replaced the injured Marcus Thuram at halftime and redeemed himself after missing a couple of golden chances by scoring the winning goal 11 minutes from time.

"I'm sorry for Marcus, I never want a player to get injured," Arnautović told Italian broadcaster Mediaset. "These are my opportunities, I come on to make the difference … it's not an easy period for me but the third chance went in."

Initial reports were that Thuram injured a muscle in his right thigh and Inter will be hoping to have the France forward back for the second leg in Madrid on March 13.

"The hope is to lose him (Thuram) for little time," Inter coach Simone Inzaghi said, after praising Arnautović.

"He will be very precious to us as he has been so far … We were obviously disappointed with the chances he missed but forwards should be worried when they don't have chances. I was a forward, there were periods when I didn't have chances and I was much more worried than when I had them and didn't manage to finish them off."

Inter stretched its perfect record this year to nine wins, while it was a third loss in four matches for Atlético.

The Spanish team didn't have a single shot on target at San Siro but will be hoping they can take lessons learned into the return at the Wanda Metropolitano stadium.

"I am optimistic obviously. We still have the opportunity to fight," Atletico coach Diego Simeone said. "We know what we are going to face, we know how they play — we just played them — and I hope that we will be able to take our chance."

PSV Eindhoven and Borussia Dortmund drew 1-1 in Tuesday's other match.

Inter was a surprise Champions League finalist last year but appears to have stepped up a level since and looks to be storming to the Serie A title after building a nine-point advantage — and with a game in hand.

It was a cagey first half at San Siro until Inter appeared to wake up nine minutes before the break.

Neither goalkeeper had really been tested before Lautaro Martínez, who had fired a good opportunity over the bar moments earlier, saw his header smothered by Jan Oblak.

Lautaro had an even better chance two minutes later when Thuram went on a surging run and rolled across for the Argentina World Cup winner but he scuffed his shot and it was deflected behind off Atlético defender José María Giménez.

Thuram also had an opportunity on the stroke of halftime but had his effort saved by Oblak and immediately then went down with a problem.

The Inter forward, who has emerged as a key player for the Nerazzurri since joining in the offseason, was able to continue after receiving treatment but went off at halftime shaking his head. His father, former Parma and Juventus defender Lilian Thuram, watched at San Siro.

Arnautović could have made an immediate impact when he came sliding in to meet a Federico Dimarco cross only to balloon it over the bar. He later fired another attempt narrowly over after sumptuous play with Lautaro.

Álvaro Morata was brought on by Atlético in the 54th minute, making his return from injury earlier than expected, and immediately set up Lino but he fired wide of the left post.

The visitors had an even better opportunity moments later when Marcos Llorente was sent through on goal but Inter defender Stefan de Vrij managed to get back in time for a last-ditch tackle.

Inter upped the pressure and eventually broke the deadlock when Lautaro surged forward and although Oblak managed to parry his effort Arnautović drilled home the rebound.

PSV Eindhoven 1, Borussia Dortmund 1

Luuk de Jong converted a penalty to cancel out a goal by his former teammate Donyell Malen as PSV Eindhoven and Borussia Dortmund drew in the first leg of their Champions League round of 16 matchup.

Malen scored against his old club in the 24th minute with a shot that appeared to deflect off the outstretched leg of defender Sergiño Dest.

Malen didn't wildly celebrate his first Champions League goal since December 2021, instead holding both hands in the air almost apologetically.

The goal was a familiar sight for the PSV fans. Malen scored 50 times in 81 appearances for the Eindhoven club from 2018-21. The crowd at PSV Stadium gave Malen a warm ovation when he was substituted late in the match.

De Jong equalized when he calmly slotted a low penalty past Alexander Meyer in the 56th minute after Mats Hummels had brought down Malik Tillman. It took De Jong's Champions League goal tally to a PSV record nine, one more than Ruud van Nistelrooy.

Dortmund players complained bitterly that Hummels had played the ball, but referee Srdjan Jovanovic waved away their protests.

"The referee judged that there was a penalty," said Dortmund coach Edin Terzic. "Our wish remains that he should look at the screen. He was very sure of his decision. We think it was a hard decision."

Hummels himself was less diplomatic.

"Zero percent a penalty. Zero. I slide in, I clearly play the ball, change its path and only then make minimal contact," the defender told Amazon Prime. "Tillman was laughing himself silly on the pitch, (Johan) Bakayoko was laughing himself silly, they were all grinning at me for minutes."

Dest came close to snatching a late winner when he passed Julian Ryerson on the left but Meyer, a late replacement for the injured Gregor Kobel, saved his shot.

"In the second half we had it completely under control," PSV midfielder Joey Veerman said. "In the first half we had the better chances. If you look at the match as a whole we had better chances than Dortmund."

The second leg is in Dortmund on March 13.

"If we can win our home game, we'll get through and that's the task for now," Terzic said.

De Jong also said he was confident heading to Dortmund.

"We played well today and we can do that there, too," De Jong said.

PSV, led by former Dortmund coach Peter Bosz, finished second behind Arsenal in Group B to reach its first Champions League round-of-16 match in eight seasons. Dortmund underlined its European pedigree by topping Group F, leaving Paris Saint-Germain in second place.

Dortmund was without striker Sébastien Haller who scored the winning goal as Ivory Coast beat Nigeria 2-1 to win the Africa Cup of Nations earlier this month. Haller, who also scored the winner in the semifinal, returned from the tournament with an ankle injury.