San Francisco - Facebook will sell advertising on its Instagram photo service, the first effort to make money from the company's largest acquisition on record.

Promotions will start to appear nationwide on the mobile application, which lets users share images from smartphones, the operator of the world's most popular social network said Thursday in a blog. Instagram will deliver a "small number" of pictures and videos from a handful of companies that users aren't necessarily following.

Facebook is seeking new ways to drive revenue from mobile devices as users increasingly access digital services from wireless devices. While mobile made up 41 percent of ad revenue in the second quarter, up from 30 percent in the previous period, Facebook remains a distant No. 2 in a market led by Google Inc., according to researcher EMarketer Inc.

"Our aim is to make any advertisements you see feel as natural to Instagram as the photos and videos many of you already enjoy from your favorite brands," Instagram said on the blog. "After all, our team doesn't just build Instagram, we use it each and every day. We want these ads to be enjoyable and creative in much the same way you see engaging, high-quality ads when you flip through your favorite magazine."