Eastbourne, England - French Open champion Francesca Schiavone and defending champion Caroline Wozniacki lost first-round matches Tuesday at the Eastbourne International.

Also beaten were fourth-seeded Agnieszka Radwanska and sixth-seeded Flavia Pennetta. Kim Clijsters fared far better in her first match on grass in nearly four years, defeating fellow Belgian Yanina Wickmayer 6-1, 6-1 in this Wimbledon warmup.

On the men's side on a blustery day, top-seeded Nicolas Almagro of Spain beat Lukasz Kubot of Poland 7-5, 7-6 (3) to line up a second round meeting with Denis Istomin of Uzbekistan.

Second-seeded Spaniard Feliciano Lopez retired after receiving shoulder treatment. He was trailing British wild card James Ward 6-3, 5-4.

Schiavone, seeded second, fell to Romania's Sorana Cirstea 7-5, 6-3. The top-seeded Wozniacki lost 6-4, 1-6, 6-3 to France's Aravane Rezai.

"She tried to take the ball early and hit every shot," Wozniacki said. "Definitely, I would like to have got some more matches here but I just need to keep my head up and play some practice matches and prepare for Wimbledon that way."

Clijsters last played on grass in the 2006 Wimbledon semifinals. On Tuesday, she ousted her 20-year-old opponent in 54 minutes.

"Yanina definitely wasn't playing her best tennis today," Clijsters said. "But at the same time from the beginning on I was very aggressive.

Top-seeded Ljubicic upset by Falla in Netherlands

At Den Bosch, Netherlands, top-seeded Ivan Ljubicic made an early exit from the Unicef Open, losing to Alejandro Falla 6-2, 7-6 (6).

Ljubicic had 12 aces but was defeated by Falla's more consistent play. The 15th-ranked Croatian won the grass court tournament three years ago.

In other play, Xavier Malisse of Belgium reached the quarterfinals for a second straight week when he beat Daniel Brands 4-6, 6-1, 7-5. Malisse was within two points of losing the second-round match.

On the women's side, third-seeded Maria Kirilenko retired with an abdominal injury against Kirsten Flipkens of Belgium.