Broncos 24, Steelers 17

Nose tackle Shelby Harris picked off Ben Roethlisberger's 2-yard pass to Antonio Brown in the end zone with 1:03 remaining to seal Denver's win over Pittsburgh on Sunday that snapped the Steelers' six-game winning streak.

The Broncos (5-6) used four takeaways to counter a 97-yard touchdown toss from Roethlisberger to JuJu Smith-Schuster.

Roethlisberger was 41 of 56 for 462 yards, but he was intercepted twice and the Steelers (7-3-1) lost two fumbles in losing for the first time since September.

Phillip Lindsay rushed for 110 yards and the game-deciding touchdown on just 14 carries for Denver, which also ended the Chargers' six-game winning streak last week and would have snapped Houston's five-game roll were it not for a missed field goal as time expired.

Vikings 24, Packers 17

Kirk Cousins bounced back from his worst game for Minnesota with 342 passing yards and three touchdowns without a turnover, and the Vikings overcame some early gaffes to outlast depleted Green Bay.

Completing 29 of his 38 attempts, Cousins found Dalvin Cook, Stefon Diggs and Adam Thielen for scores. Sheldon Richardson had two sacks to lead the defense's game-long stifling of Aaron Rodgers, and the Vikings (6-4-1) pushed the Packers (4-6-1) further back in the NFC wild card race.

Rodgers threw a touchdown pass to Davante Adams and Aaron Jones scored on a short run for a 14-7 lead early in the second quarter, but the Packers fell to 0-6 on the road this season and 1-5-1 against the Vikings in their last seven meetings.

With Randall Cobb out (hamstring) for a sixth game this season and rookies Equanimeous St. Brown (elbow) and Trevor Davis (hamstring) forced out in the second half, Rodgers didn't have much to work with down the field. Left guard Lane Taylor (quadriceps) departed in the first half and left tackle David Bakhtiari (knee) was sidelined in the second half, leaving the protection shaky at best. Rodgers finished 17 for 28 for 198 yards, without a turnover.

Colts 27, Dolphins 24

Andrew Luck threw three touchdown passes, Adam Vinatieri kicked a 32-yard field goal as time expired and Indianapolis beat Miami for its fifth consecutive victory.

Indianapolis (6-5) scored 13 points in the final 8½ minutes to erase a 10-point deficit. It's the longest win streak for the Colts since 2014.

Miami (5-6) has lost 10 of its past 11 on the road, perhaps none more frustrating than this one. The Dolphins picked off Luck twice, recovered a fumble and partially blocked a punt on their way to a 24-14 lead.

It still wasn't enough to derail the resurgent Luck, who was 30 of 37 for 343 yards. He also had the first catch of his NFL career, a 4-yard reception on fourth-and-1 late in the first half. Luck capped that drive with a 1-yard TD pass to Jack Doyle.

Seahawks 30, Panthers 27

Russell Wilson threw for 339 yards and two touchdowns and Sebastian Janikowski kicked a 31-yard field goal as time expired to lift Seattle to a come-from-behind victory over Carolina.

After Graham Gano missed a 52-yard field goal with 1:40 left in the game that would have given the Panthers the lead, Wilson moved around in the pocket until finding Tyler Lockett downfield for a 43-yard completion, setting up the winning kick.

The victory puts Seattle (6-5) firmly in the hunt for a wild-card spot in the NFC, while the Panthers (6-5) are reeling after losing three straight and having their 10-game home winning streak snapped.

Lockett finished with five catches for 107 yards and a touchdown, while David Moore had four receptions for 103 yards and a score.

The Panthers spoiled a record-setting performance from Christian McCaffrey, who had a franchise-record 237 yards from scrimmage. He had 17 carries for 125 yards and 11 catches for 112 yards, becoming the first Carolina player to surpass 100 yards in both receiving and rushing in the same game.

Cam Newton finished 25 of 30 for 256 yards with two touchdown passes and one interception in the end zone. He ran for 63 yards on eight carries.

Browns 35, Bengals 20

Baker Mayfield threw a career-high four touchdown passes in another growing-up-fast performance, and Cleveland ended one of the NFL's longest streaks of road futility with a victory over Cincinnati, which lost quarterback Andy Dalton to a thumb injury.

Cleveland (4-6-1) got its first road win since 2015, emphatically snapping a streak of 25 straight road losses that was one shy of the Lions' NFL record. The Browns also ended a run of seven straight losses to their intrastate rival.

And just as a Browns safety predicted, it wasn't even close.

The Browns surged ahead 28-0 as former head coach Hue Jackson watched helplessly from the opposite sideline. Jackson couldn't win with the Browns — only three wins in two-plus seasons. Nor could he couldn't beat them as a special defensive assistant with the Bengals (5-6), who lost for the fifth time in six games.

Chargers 45, Cardinals 10

Philip Rivers tied the NFL record for consecutive completions and set marks for the most to start a game and the highest percentage in a game and Los Angeles rolled over Arizona.

The 15-year veteran completed his first 25 passes and was 28 of 29 for 259 yards and three touchdowns in three quarters. It was also his 11th straight game with multiple TD passes.

Rivers completed 25 straight passes in the first 2½ quarters, tying Ryan Tannehill's mark from 2015. The Dolphins QB completed his last seven passes against the Tennessee Titans in on Oct. 18, 2015, and then his first 18 the following week against the Houston Texans.

Rivers tied the mark with a 4-yard touchdown pass to Keenan Allen midway through the third quarter. He had his only incompletion on the next possession when he was rushed and was unable to connect on a short pass to Austin Ekeler.

Rivers did break Mark Brunell's record for most completions to start a game. Brunell had 22 straight for the Washington Redskins against the Houston Texans on Sept. 24, 2006. Rivers' 96.8 percent accuracy surpassed Kurt Warner's 92.3 percent, which was set in 2009 when he went 24 of 26 for Arizona against Jacksonville.

The Cardinals (2-9) jumped out to a 10-0 lead with scores on their first two possessions before the Chargers (8-3) scored touchdowns on six of seven possessions.

Ravens 34, Raiders 17

Rookie quarterback Lamar Jackson ran for a touchdown and threw for a score, Terrell Suggs returned a fumble 43 yards for a TD and Baltimore ran past Oakland.

Cyrus Jones took a punt 70 yards for a touchdown to help the Ravens (6-5) win a second straight game for the first time since September.

Gus Edwards rushed for 118 yards as part of an effective ground game that enabled Jackson to pass just enough to keep the Raiders (2-9) off guard — and off the field. Baltimore expanded a three-point halftime lead to 27-17 with two run-heavy touchdown drives that consumed a total of nearly 16 minutes.

With starter Joe Flacco out for a second straight game with an injured right hip, Jackson cut down on his rushing attempts, threw more often and got the same result — a victory. After carrying 27 times for 117 yards last week in his NFL starting debut, Jackson ran 11 times for 71 yards and went 14 for 25 for 178 yards and two interceptions.

Suggs clinched it with 5:55 left, lumbering down the right sideline after Oakland's Derek Carr was sacked by Matthew Judon and lost the ball on a fourth-down play.

Bills 24, Jaguars 21

Josh Allen scored the go-ahead touchdown on a 14-yard run in the fourth quarter, and the Bills beat the Jaguars in a game marred by a fight that led to the ejections of Jacksonville running back Leonard Fournette and Buffalo defensive end Shaq Lawson.

Fournette scored twice to tie it at 14 in the second quarter. He finished with 95 yards on 18 carries before he was thrown out with 2:57 left in the third.

Allen also threw a 75-yard touchdown pass to Robert Foster in the rookie quarterback's first game since missing four with a sprained throwing elbow. Rookie receiver Isaiah McKenzie scored on a 6-yard run off a sweep, and Buffalo (4-7) came off its bye week off to win consecutive games for the first time this season.

The Jaguars (3-8) dropped their seventh consecutive game in their longest losing streak since a nine-game slide in 2016, which led directly to Gus Bradley being fired and replaced by current coach Doug Marrone.

Buccaneers 27, 49ers 9

Jameis Winston threw for 312 yards and two touchdowns to help Tampa Bay snap a four-game losing streak.

Winston, benched last month after turning the ball over 11 times in 14 quarters, completed 29 of 38 passes without an interception.

The fourth-year pro, who's shared the starting job with Ryan Fitzpatrick, tossed scoring passes of 6 yards to Cameron Brate and 28 yards to Adam Humphries on a play he extended by scrambling to his right before throwing back toward the center of the field.

Tampa Bay (4-7), meanwhile, had four sacks and forced a turnover on defense for the first time in eight games, with Ryan Smith and Isaiah Johnson coming up with the team's first interceptions since a loss to Pittsburgh on Sept. 24.

Matt Breida rushed for 106 yards for the 49ers (2-9).