Children and their parents often suffer serious disputes, but they rarely make them into a sitcom. That’s exactly what comedian George Lopez and his daughter, Mayan, have done with “Lopez vs. Lopez,” airing Fridays on NBC.

“My parents got divorced about 10 years ago,” recalls Mayan Lopez, 26. “There was a time where we didn’t speak and were estranged for about three years. But the pandemic brought us back together. And within the last two years, my dad and I really solidified our relationship.”

Mayan says she started creating TikToks to try to reconnect with her family. “And (TV producer) Debby Wolfe was scrolling one day and she saw one of our TikToks. And this whole ‘Lopez vs. Lopez’ was born from that idea.”

The elder Lopez is no newcomer to comedy. He started as a stand-up comedian and helmed his own series, “George Lopez,” on ABC for six seasons. He hosted the late-night talk show on TBS called “Lopez Tonight,” and enjoyed a brief sitcom stint in “Saint George” on FX.

“To leave (TV) for 15 years and to have Debby see Mayan do TikToks about our unfortunate break in our relationship ... to create a beautiful thing from something that was so painful and so much my fault is just a wonderful thing,” says Lopez.

“This is an experience of a lifetime, to be able to do this with my father,” adds Mayan.

“I have studied personally to be a comedian,” she continues. “But the inception of my love of comedy started at a young age. And the ‘George Lopez’ show started when I was 5 years old. So I’ve been around sound sets. ... And now, making that switch to working with him every day ...

“I’m playing a different version of myself, which at first I thought, ‘Oh, well, I’ve gone to therapy!’ Like, I’m going to be teaching ‘Mayan the character’ some things about my dad, but, really, ‘Mayan’ is teaching me things that I’m actually gaining more confidence in my relationship with my dad.”

She thinks that functioning as coworkers changes the whole complexion of their relationship. “There has to be some emotional separation, but the bond and the love shows very clearly on screen — not just with my dad but with the entire cast of ‘Lopez vs. Lopez.’ And so it is just — it’s a beautiful, beautiful thing.”

As for her dad, he says, “When I look at Mayan, I can see the different times in her life every day,” says Lopez. “I look at her being 5 and 10 and 13. I mean, my eyes have seen a lot of incredible things, but what I get to see every day, I never imagined would ever be something I would be able to do.”

Being back on NBC is doubly gratifying for Lopez, 61. “I was on ‘Johnny Carson’ in ‘91. ... I came here when I was 13 and saw all the things that people see today. And to just know that Johnny Carson, Freddie Prinze, ‘Sanford and Son’ (all aired on NBC) at the most critical time of my childhood, my junior high years, that those people kept me connected to just not having the loneliest childhood. And the fact that I would be here and be able to see these trams go by, when I was IN the tram ... it’s unimaginable to me.”

Lopez, who was deserted by his father at birth and by his mother when he was 10, was raised by his grandmother, so family is important to him.

“I used to give up on people,” he says, “whether it was my fault or not. I would remove people from my life. And if I was to blame, I would just never have to see them again. But this is the one relationship that is the most valuable thing to me in my entire life. So it was very difficult to be able to have to look at yourself and your flawed self and be honest with yourself and know that whether it worked out or not, I was going to do something that was entirely new to me and was going to take me on a very painful journey to look at myself. But much like life, laughter is the best medicine. I don’t think it’s as good as antidepressants, but it can be a good medicine.”